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Kick-It Game Event

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I understand that my consent to these provisions is given in consideration for being permitted to participate in this Event. I further understand that I may be removed from this competition if I do not follow all the rules of this Event. I am a voluntary participant in this Event, and in good physical condition. I know that this Event is a potentially hazardous activity and I hereby voluntarily assume full and complete responsibility for, and the risk of, any injury or accident that may occur during my participation in this Event or while on the premises of this Event. I, for myself, my next of kin, my minor children, my heirs, administrators, and executors, hereby release and hold harmless and covenant not to file suit against Flashes of Hope, Inc. or any affiliated individuals, any Event sponsors and their agents and employees, and all other persons or entities associated with this Event (Collectively, the "Releasees") for any injury or damages I might suffer in connection with my participation in this Event or while on the premises of this Event. This release applies to any and all loss, liability, or claims I may have arising out of my participation in this Event, including but not limited to, personal injury or damage suffered by me or others, whether such losses, liabilities or claims be caused by falls, contact with and/or actions of other participants, contact with fixed or non-fixed objects, contact with animals, conditions of the premises of the Event, negligence of the Releasees, risks not known to me or not reasonably foreseeable at this time, or otherwise.

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We're playing kickball to support families that have been affected by pediatric cancer! Please join us for a great day of fun and show your support for this great cause. If you can't attend, you can still help us reach our goal through your generous donation. Please join the fight against pediatric cancer and help us kick it!

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We're playing kickball to support families that have been affected by pediatric cancer and you've been personally invited to start or join a team! Please join us for a great day of fun and show your support for this great cause. If you can't attend, you can still help us reach our goal through your generous donation. We hope you'll help us kick it and join the fight against pediatric cancer!

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I’m teaming up with Kick-It to cure childhood cancer one KICK at a time! Please join the fight against pediatric cancer and help us kick it!

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We work closely with our partners to fund lab research of rare and underfunded pediatric cancers. We support clinical research in local hospitals through the work of the Children’s Oncology Group.

2016 Research Projects


Children's Oncology Group - EveryChild Initiative
USA
Funding Partner: Jeff Gordon Children's Foundation

Research Institute at Nationwide Children's Hospital
Columbus, OH
Kevin Cassady & Christopher Walker
Improving Immune-Mediated Oncolytic Viral Therapy: Engineering Tumor Vaccine Elements into the Virus
Funding Partner: Alex's Lemonade Stand

Research Institute at Nationwide Children's Hospital
Columbus, OH
Researcher: Kathleen Pishas
Pre-clinical Evaluation of LSD1 Inhibitors for the Treatment of Pediatric Ewing's Sarcoma
Funding Partner: Alex's Lemonade Stand

Brigham's and Women's Hospital
Boston, MA
Cichowski, Karen
Merestinib (MNKi) + MEKi for the treatment of MPNST
Funding Partner: Children's Tumor Foundation

Brigham's and Women's Hospital
Boston, MA
Cichowski, Karen
Romidepsin (HDACi) + mTORi for the treatment of MPNST
Funding Partner: Children's Tumor Foundation

California Institute of Technology
Pasadena, CA
John E. Robinson
Utilizing CLARITY, optogenetics, and novel viral vectors to deconstruct and reverse ADHD-like phenotypes associated with neurofibromatosis type 1
Funding Partner: Children's Tumor Foundation

University of Texas Southwestern Medical Center
Dallas, TX
Jean-Philippe Brosseau
Fibroblasts: The missing gap in Neurofibromatosis
Funding Partner: Children's Tumor Foundation

Geisel School of Medicine at Dartmouth College
Hanover, NH
Stephanie J. Bouley
Targeting tumors with NF1 loss via modulation of autophagy
Funding Partner: Children's Tumor Foundation

Brigham and Women's Hospital
Boston, MA
Thomas DeRaedt (K.Cichowski lab)
Developing an advanced in vivo modeling system to test drivers and explore therapies for NF1 associated central nervous system tumors
Funding Partner: Children's Tumor Foundation

Johns Hopkins University
Baltimore, MD
Verena Staedtke
Evaluation of Mebendazole as Chemoprevention in a Neurofibromatosis 1 Transgenic Mouse Model
Funding Partner: Children's Tumor Foundation

University of Pennsylvania
Philadelphia, PA
Jeffrey Field
MPNST profiling and screening: extension for exome sequencing of the cell lines screened
Funding Partner: Children's Tumor Foundation

Columbia University
New York, NY
Antonio Iavarone
Identification, functional characterization and therapeutic exploitation of the integrated landscape of genetic and epigenetic alterations in glioma from patients with NF1
Funding Partner: Children's Tumor Foundation

The Washington University, Children's Hospital of Philadelphia, UCSF, DKFZ (Germany)
International Consortium
David Gutmann, Michael Fisher, Bill Weiss, Stefan Pfister, David Jones, Joanna Phillips, Adam Resnik, Angela Waanders
Identification, functional characterization and therapeutic exploitation of the integrated landscape of genetic and epigenetic alterations in glioma from patients with NF1
Investigators
Funding Partner: Children's Tumor Foundation

Medical University of South Carolina
Charleston, SC
Steven Lewis Carroll
Combinatorial Therapy with Receptor Tyrosine Kinase Inhibitors for Malignant Peripheral Nerve Sheath Tumors
Funding Partner: Children's Tumor Foundation

Cincinnati Children's Hospital Medical Center
Cincinnati, OH
Nancy Ratner
Mechanisms of Resistance to MEK Inhibition in Neurofibroma
Funding Partner: Children's Tumor Foundation

Massachusetts General Hospital
Boston, MA
Andrea McClatchey
Expanded testing of centrosome-unclustering drugs in NF2-mutant tumors
Funding Partner: Children's Tumor Foundation

University of Chicago
Chicago, IL
Mark Applebaum
Identification of Hypoxia Induced Pathways Driving Aggressive Neuroblastoma
Funding Partner: Bear Necessities Pediatric Cancer Foundation

Dana Farber Cancer Institute
Boston, MA
Mark Kieran
DIPG research and clinical trials
Funding Partner: Prayers From Maria

Cleveland Clinic Children's Hospital
Cleveland, OH
Rabi Hanna
Quantification of therapeutic responses in pediatric and adolescents and young adults (AYA) Lymphoma patients via detection of circulating tumor DNA
Funding Partner: Cleveland Clinic Children's Hospital


Children’s Oncology Group – EveryChild Initiative
Funding Partner:  Jeff Gordon Children’s Foundation

Brigham’s and Women’s Hospital
Boston, MA
Cichowski, Karen
Project Title: Hsp90 + MEK: STA-1474 + PD0325901 or AZD6244 for the treatment of MPNST
Funding Partner:  Children’s Tumor Foundation

Brigham’s and Women’s Hospital
Boston, MA  
Cichowski, Karen
Project Title:  KRAS (+ MEK): Antisense oligonucleotide KRas (+ PD0325901 or AZD2014) for the treatment of MPNST
Funding Partner:  Children’s Tumor Foundation

Brigham’s and Women’s Hospital
Boston, MA
Cichowski, Karen
Project Title: HDAC + mTOR: mTOR inhibitors (INK128 and AZD2014) and HDAC inhibitors (entinostat + either belinostat or romidepsin for the treatment of MPNST)
Funding Partner:  Children’s Tumor Foundation

Dana-Farber Cancer Institute
Boston, MA
A. Thomas Look Boston, MA
Project Title:  Drug discovery for NF1-associated malignant peripheral nerve sheath tumors using the zebrafish model
Funding Partner:  Children’s Tumor Foundation

Medical University of South Carolina
Charleston, SC
Steven Lewis Carroll
Project Title:  Combinatorial Therapy with Receptor Tyrosine Kinase Inhibitors for Malignant Peripheral Nerve Sheath Tumors
Funding Partner:  Children’s Tumor Foundation

Cincinnati Children's Hospital Medical Center
Cincinnati, OH
Nancy Ratner
Project Title:  Mechanisms of Resistance to MEK Inhibition in Neurofibroma
Funding Partner:  Children’s Tumor Foundation

University of Pennsylvania
Philadelphia, PA
Jeffrey Field
Project Title:  MPNST profiling and screening: an experiment in Research based Education model
Jeffrey Field
Funding Partner:  Children’s Tumor Foundation

CASE Western Reserve University/UH Rainbow Babies and Children
Cleveland, OH
Staff
Project Title:  The Phase I/II Trials Collaborative for Children, Adolescents, and Young Adults at UH Rainbow Babies & Children's Hospital and the Case Comprehensive Cancer Center
Funding Partner:  Alex’s Lemonade Stand

Children's Research Institute at Nationwide Children's Hospital
Columbus, OH
Staff
Project Title:  Clinical Research - General Pediatric Cancer
Funding Partner:  Alex’s Lemonade Stand

Dana Farber Cancer Institute
Boston, MA
Mark Kieran & Dipak Panigrahy 
Project Title:  Regulation of Tumor Debris Mediated Inflammation as a Therapeutic Modality in Medulloblastoma
Funding Partner:  Alex’s Lemonade Stand

Children’s Hospital of Los Angeles
Los Angeles, CA
Robert Seeger & Alan Wayne
Project Title:  Anitbody Targeted Natural Killer Cell-Delivered Extracellular Vesicles for the Treatment of Childhood Acute Lymphoblastic Leukemia and Neuroblastoma
Funding Partner:  Alex’s Lemonade Stand

Massachusetts General Hospital
Boston, MA
Andrea McClatchey
Project Title:  Expanded testing of centrosome-unclustering drugs in NF2-mutant tumors
Funding Partner:  Children’s Tumor Foundation

University of California
San Francisco, CA
Kevin Shannon
Project Title:  PRC2 complex: PLX51107, Bet-01 (Plexxikon) for the treatment of JMML
NF1 JMML, Scientific Model Systems  - Individual efforts as part of Consortium  
Funding Partner:  Children’s Tumor Foundation

The Children's Hospital of Philadelphia
Philadelphia, PA
Sarah Richman
Project Title:  Regulating CAR T cell activity for targeting solid tumors
Funding Partner:  St. Baldrick’s Foundation

Case Western Reserve University
Cleveland, OH
Agne Petrosiute
Project Title:  Cdk5 Confers Tumor Resistance to Adaptive Immunity by PDL1 Upregulation
Immunology
Funding Partner:  St. Baldrick’s Foundation

John Hopkins University
Baltimore, MD
Catherine Albert
Project Title:  NF kappa B is a novel therapeutic target in pediatric rhabdomyosarcoma                                                                            
Funding Partner:  Bear Necessities Pediatric Cancer Foundation                               

St Joseph’s Hospital & Medical Center 
Phoenix, AZ                                     
Shwetal Mehta
Project Title:  A synthetic lethal screen for pediatric low grade astocytoma
Funding Partner:  Bear Necessities Pediatric Cancer Foundation     

Northwestern University
Chicago, IL
Rintaro Hashizume
Project Title:  Targeted inhibition of histone demethylase activity in brainstem glioma (DIPG)
Funding Partner:  Bear Necessities Pediatric Cancer Foundation                                  

University of Pennsylvania
Philadelphia, PA
Jeffrey Field
Project Title:  MPNST profiling and screening: an experiment in Research based Education model
Funding Partner:  Children’s Tumor Foundation

Cleveland Clinic Children’s Hospital
Cleveland, OH
Violette Recinos
Project Title:  Inhibition of Histone Methyltransferase with Novel Epipolythiodioxopiperazines (ETP) Alkaloids in Pediatric High Grade Glioma
Funding Partner:  Cleveland Clinic Children’s Hospital


CASE Western Reserve University/UH Rainbow Babies and Children
Robin Elizabeth Norris
Cleveland, OH
The Phase I/II Trials Collaborative for Children, Adolescents, and Young Adults at UH Rainbow Babies & Children's Hospital and the Case Comprehensive Cancer Center
Funding Partner: Alex’s Lemonade Stand

Children's Research Institute at Nationwide Children's Hospital
Timothy Cripe
Columbus, OH
Phase I/II General Pediatric Cancer, Leukemia and Neuroblastoma
Funding Partner: Alex’s Lemonade Stand

Harvard University Brigham & Women's Hospital
Karen Cichowski
Boston, MA
NFTC: Neurofibromatosis Therapeutic Consortium Vorinostat + rapamycin for the treatment of MPNST
Funding Partner: Children’s Tumor Foundation

Harvard University Brigham & Women's Hospital
Karen Cichowski
Boston, MA
NFTC: Neurofibromatosis Therapeutic Consortium ABT-263 + rapamycin for the treatment of MPNST
Funding Partner: Children’s Tumor Foundation

Harvard University Brigham & Women's Hospital
Karen Cichowski
Boston, MA
NFTC: Neurofibromatosis Therapeutic Consortium Anti-PD1 AB + JQ1 + PD-901 for the treatment of MPNST
Funding Partner: Children’s Tumor Foundation

The University of Texas MD Anderson Cancer Center
Christine Kivlin
Houston, TX
PARP inhibitors for the treatment of (NF1-associated) MPNST
Funding Partner: Children’s Tumor Foundation

Dana-Farber Cancer Institute
Shuning He
Boston, MA
In vivo analysis of the NF1 tumor suppressor in neurofibromatosis
Funding Partner: Children’s Tumor Foundation

Harvard University Brigham & Women's Hospital
Claire Malone
Boston, MA
Identifying novel therapeutic combinations that target cell vulnerabilities in MPNSTs
Funding Partner: Children’s Tumor Foundation

Geisel School of Medicine at Dartmouth College
Robert Allaway
Hanover, NH
Characterizing novel therapeutics that exhibit synthetic lethality with NF1-associated tumors
Funding Partner: Children’s Tumor Foundation

Cleveland Clinic Children’s Hospital
Charis Eng, MD, PhD and Johannes Wolff, MD
Cleveland, OH
Exome sequencing in children, and adolescents and young adult (AYA) patients with malignancies
Funding Partner:  Cleveland Clinic Foundation

John Hopkins University
Catherine Albert
Baltimore, MD
NF kappa B is a novel therapeutic target in pediatric rhabdomyosarcoma
Funding Partner: Bear Necessities Pediatric Cancer Foundation

St Joseph’s Hospital & Medical Center
Shwetal Mehta
Phoenix, AZ
A synthetic lethal screen for pediatric low grade astocytoma
Funding Partner:  Bear Necessities Pediatric Cancer Foundation

Northwestern University
Rintaro Hashizume
Chicago, IL
Targeted inhibition of histone demethylase activity in brainstem glioma (DIPG)
Funding Partner: Bear Necessities Pediatric Cancer Foundation


Children’s Oncology Group
Columbus, OH
EveryChild Initiative 
Funding Partner: Jeff Gordon Children’s Foundation 

Nationwide Children’s Hospital
Jaiyuh Lin
Columbus, OH
Novel STAT3 drug development for childhood osteosarcoma therapy using drug repositioning
Funding Partner: Alex’s Lemonade Stand Foundation

The Children’s Hospital of Philadelphia
Daniel Weiser 
Philadelphia, PA
Development of a Prediction Model for Primary Refractory Neuroblastoma
Funding Partner: Bear Necessities Pediatric Cancer Foundation 

Baylor College of Medicine
Jason Yustein
Waco, TX
Dissecting and Targeting the WNT Pathway in Metastatic Osteosarcoma
Funding Partner: Bear Necessities Pediatric Cancer Foundation 

Dana-Farber Cancer Institute 3
Brian Compton
Boston, MA
Targeting FAK and integrin signaling in preclinical models of Ewing sarcoma
Funding Partner: Bear Necessities Pediatric Cancer Foundation 

Children’s Hospital of Philadelphia
Michael Fisher
Philadelphia, PA
Phase I Trial of AZD6244 on Plexiform Neurofibromas
Funding Partner: Children’s Tumor Foundation 

Harvard Medical School/Brigham & Women’s Hospital
Rebecca Lock
Boston, MA
NF1 Malignant Peripheral Nerve Sheath Tumors
Funding Partner: Children’s Tumor Foundation


2012 Research Projects

Rainbow Babies & Children’s Hospital 5
Children’s Oncology Group
Cleveland, OH
COG Phase III ALL and Brain Tumor Clinical Trials
Funding Partner: Curesearch 

Cleveland Clinic Children’s Hospital
Children’s Oncology Group
Cleveland, OH
COG Phase III ALL and Brain Tumor Clinical Trials
Funding Partner: Curesearch

Children’s Memorial Hospital (Lurie Children’s Hospital)
Risha Lulia
Chicago, IL
Longitudinal profiling of microRNA expression in patients with CNS tumors
Funding Partner: Bear Necessities Pediatric Cancer Foundation 

Memorial Sloan-Kettering Cancer Center
Stephen Roberts
New York, NY
Neuroblastoma-causing Mutations in Human Neural Crest Stem Cells
Funding Partner: Bear Necessities Pediatric Cancer Foundation 

Cincinnati Children’s Hospital Medical Center
Janos Sumegi
Cincinnati, OH
PAX3-NCOA1 and PAX3-NCOA2 Downstream Target Genes in Rhabdomyosarcoma
Funding Partner: Bear Necessities Pediatric Cancer Foundation 

Children’s Hospital of Philadelphia
Michael Fisher
Philadelphia, PA
Phase I Trial of AZD6244 on Plexiform Neurofibromas
Funding Partner: Children’s Tumor Foundation 

Harvard Medical School/Brigham & Women’s Hospital
Karen Cichowski
Boston, MA
NF1 Malignant Peripheral Nerve Sheath Tumors
Funding Partner: Children’s Tumor Foundation 

Case Western Reserve University
Alex Huang
Cleveland, OH
Developing immune-modulatory strategies against primary and metastatic tumors in the central nervous system
Funding Partner: Alex’s Lemonade Stand Foundation 



2011 Research Projects

Rainbow Babies & Children’s Hospital
Children’s Oncology Group
Cleveland, OH
COG Phase III ALL and Brain Tumor Clinical Trials
Funding Partner: Curesearch 

Cleveland Clinic Children’s Hospital
Children’s Oncology Group
Cleveland, OH
COG Phase III ALL and Brain Tumor Clinical Trials
Funding Partner: Curesearch 

Harvard Medical School/Brigham & Women’s Hospital
Karen Cichowski
Boston, MA
NF1 Malignant Peripheral Nerve Sheath Tumors
Funding Partner: Children’s Tumor Foundation 



2010 Research Projects

Harvard Medical School/Brigham & Women’s Hospital
Karen Cichowski
Boston, MA
NF1 Malignant Peripheral Nerve Sheath Tumors
Funding Partner: Children’s Tumor Foundation 

Rainbow Babies & Children’s Hospital
Children’s Oncology Group
Cleveland, OH
Pediatric, Adolescent and Young Adult Cancer Clinical Trials
Funding Partner: Curesearch 

Cleveland Clinic Children’s Hospital
Children’s Oncology Group
Cleveland, OH
Pediatric, Adolescent and Young Adult Cancer Clinical Trials
Funding Partner: Curesearch



2009 Research Projects

Harvard Medical School/Brigham & Women’s Hospital
Karen Cichowski
Boston, MA
NF1 Malignant Peripheral Nerve Sheath Tumors
Funding Partner: Children’s Tumor Foundation 

Rainbow Babies & Children’s Hospital
Children’s Oncology Group
Cleveland, OH
Pediatric, Adolescent and Young Adult Cancer Clinical Trials
Funding Partner: Curesearch 

Cleveland Clinic Children’s Hospital
Children’s Oncology Group
Cleveland, OH
Pediatric, Adolescent and Young Adult Cancer Clinical Trials
Funding Partner: Curesearch 

National Sponsors

Children's Oncology GroupCleveland CavaliersBear NecessitiesKohl's Professional Camps

Upcoming Events & Fundraisers

Hospitality Restaurants

Saturday, April 01, 2017

Fairview Park, OH

AT&T Kicks It For Kids with Cancer 2017

Saturday, April 01, 2017

Cleveland, OH

TLC KICK IT TOURNAMENT

Sunday, April 09, 2017

Sandusky, OH

Recent Events & Fundraisers

Kick it @Shaker Heights

Sunday, May 07, 2017

Shaker Heights, OH

PIN PEDIATRIC CANCER

Saturday, December 03, 2016

Aurora, OH

Thomas' GOAL is to ASSIST Cancer Research

Saturday, November 26, 2016

Any City, NJ